PERFORIN (M) Antibody, Rabbit Polyclonal

Biorbyt

PERFORIN antibody

16

WB:1:1000-1:5000 WB

Pdgfb

platelet derived growth factor, B polypeptide

c-sis; PDGF-; PDGF subunit B; PDGF-2; PDGF-B; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide; platelet-derived growth factor subunit B; proto-oncogene c-Sis; Sis

Platelet-derived growth factor subunit B

Rabbit polyclonal to PERFORIN.PERFORIN (PRF1) is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Upondegranulation, PERFORIN inserts itself into the target cells plasma membrane, forming a pore. Thelytic membrane-inserting part of PERFORIN is the MACPF domain, which shares homology withcholesterol-dependent cytolysins from Gram-positive bacteria. PERFORIN has structural andfunctional similarities to complement component 9 (C9). Like C9, PERFORIN creates transmembranetubules and is capable of lysing non-specifically a variety of target cells. PERFORIN is one of themain cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cellandnatural killer-cell-mediated cytolysis. Defects in PERFORIN cause familial hemophagocyticlymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood.

-20°C

12352203