Petosemtamab (FUT8-KO)

MedChem Express

Petosemtamab (FUT8-KO)

5

Research Use Only

Monoclonal

Petosemtamab (FUT8-KO) is a knockout version of petosemtamab for the fucosyltransferase 8 gene (FUT8). Petosemtamab (HY-P99406) is an anti- EGFR ( K d : 0.22 nM) and anti- LGR5 ( K d : 0.86 nM) monoclonal antibody (mAb). Petosemtamab leads to blockade of EGFR signaling and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the study of solid tumors such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC), etc [1] [2] .

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