Pevonedistat [905579-51-3]

MedChem Express

Pevonedistat [905579-51-3]

10

905579-51-3

CHEMICAL,general_chemicals_reagents

Research Use Only

99.98

C21H25N5O4S

443.52

Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice[1].

O=S(OC[C@@H]1C[C@@H](N2C3=NC=NC(N[C@H]4CCC5=C4C=CC=C5)=C3C=C2)C[C@@H]1O)(N)=O

-20°C, 3 years; 4°C, 2 years (Powder)

12352005