Pevonedistat (Standard) [905579-51-3]
HY-70062R
Product group Assays
Overview
- SupplierMedChem Express
- Product NamePevonedistat (Standard) [905579-51-3]
- Delivery Days Customer999
- CertificationResearch Use Only
- Scientific DescriptionPevonedistat (Standard) is the analytical standard of Pevonedistat. This product is intended for research and analytical applications. Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice[1].
- UNSPSC41116100