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PF-04418948 [1078166-57-0]

PF-04418948 [1078166-57-0]

T3306
TargetMol Chemicals
CAS Number1078166-57-0
Product group Chemicals
Estimated Purity99.45%
Molecular Weight409.41
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    PF-04418948 [1078166-57-0]
  • Delivery Days Customer
    4
  • CAS Number
    1078166-57-0
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    PF-04418948
  • Estimated Purity
    99.45%
  • Molecular Formula
    C23H20FNO5
  • Molecular Weight
    409.41
  • Scientific Description
    PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 microM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).
  • Shelf life instruction
    3 years
  • SMILES
    COc1ccc2cc(OCC3(CN(C3)C(=O)c3ccc(F)cc3)C(O)=O)ccc2c1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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