PF-04856264

MedChem Express

PF-04856264 [1235397-05-3]

10

1235397-05-3

Research Use Only

99.0

C20H15N5O3S2

437.49

PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC 50 s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect [1] [2] .

O=S(C1=CC=C(OC2=CC=CC=C2C3=CC=NN3C)C(C#N)=C1)(NC4=NC=CS4)=O

-20°C,2°C to 8°C

12352200