PF-05186462 [1235406-03-7]

MedChem Express

PF-05186462 [1235406-03-7]

10

1235406-03-7

Research Use Only

99.69

C19H10ClF4N5O3S2

531.89

PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8). PF-05186462 can be used for the research of acute or chronic pain[1].

O=S(C1=CC(Cl)=C(OC2=CC=C(C(F)(F)F)C=C2C3=CC=NN=C3)C=C1F)(NC4=NN=CS4)=O

-20°C

12352200