PF-06445974 [2055776-17-3]

MedChem Express

PF-06445974 [2055776-17-3]

10

2055776-17-3

Research Use Only

98.59

C20H15FN4O

346.36

PF-06445974, a promising positron emission tomography (PET) lead, has exquisite potency at PDE4B with an IC50 50 values are 36, 4.7 and 17 nM for PDE4D, PDE4A and PDE4C, respectively. PF-06445974 has good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the cold tracer study[1].

N#CC1=CC=C(C=C1F)C2=C(C3=O)N(CCN3C4CC4)C5=CC=CN=C25

-20°C,2°C to 8°C

12352200