PF-06446846 (hydrochloride)

MedChem Express

PF-06446846 (hydrochloride) [1632250-50-0]

10

1632250-50-0

Research Use Only

99.44

C22H21Cl2N7O

470.35

PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34[1].

O=C(N(C1=NC=CC=C1Cl)[C@H]2CNCCC2)C3=CC=C(N4N=NC5=CC=CN=C54)C=C3.[H]Cl

2°C to 8°C

12352200