PF-06465469

MedChem Express

PF-06465469 [1407966-77-1]

9

1407966-77-1

Research Use Only

99.48

C30H33N7O2

523.63

PF-06465469 is a covalent inhibitor of ITK with an IC 50 of 2 nM. PF-06465469 also inhibits BTK . PF-06465469 inhibits cell migration in response to CXCL12 . PF-06465469 decreases PD-1 and LAG-3 expression. PF-06465469 can be used to study leukemia and T-cell lymphoma [1] [2] .

O=C(NC1=CC=C(C(C)C)C(C)=C1)C2=CC=CC(C3=NN([C@H]4CN(C(C=C)=O)CCC4)C5=NC=NC(N)=C53)=C2

-20°C,2°C to 8°C

12352200