PF-06737007

Biorbyt

PF-06737007 [1863905-38-7]

10

1863905-38-7

Research Use Only

C25H28F4N2O6

528.4932

PF-06737007 is a potent pan-Trk inhibitor in cell-based assays with IC50s of 7.7 nM, 15 nM and 3.9 nM for TrkA, TrkB and TrkC, respectively. Anti-hyperalgesic effect.

F[C@]1([H])C([H])([H])N(C(C([H])([H])C2C([H])=C([H])C(=C([H])C=2[H])OC(F)(F)F)=O)C([H])([H])C([H])([H])[C@@]1([H])OC1C([H])=C(C([H])=C([H])C=1C(N([H])[H])=O)OC([H])([H])C(C([H])([H])[H])(C([H])([H])[H])O[H]

12352200