PF-06815345 (hydrochloride) [2334434-49-8]

MedChem Express

PF-06815345 (hydrochloride) [2334434-49-8]

10

2334434-49-8

Research Use Only

98.15

C27H30Cl2FN9O4

634.49

PF-06815345 hydrochloride is an orally active and potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with an IC50 value of 13.4 microM. PF-06815345 hydrochloride significantly decreases the PCSK9 level in vivo in mouse[1][2].

O=C(N([C@H]1CNCCC1)C2=C(Cl)C=CC=N2)C3=CC=C(C4=C(C5=NN=NN5[C@H](C)OC(OCC)=O)N(C)N=C4)C(F)=C3.[H]Cl

2°C to 8°C

12352200