PF 477736

MedChem Express

PF 477736 [952021-60-2]

10

952021-60-2

99.21

C22H25N7O2

419.48

PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1 , with a K i of 0.49 nM, it is also a Chk2 inhibitor, with a K i of 47 nM. PF 477736 shows VEGFR2 , Fms , Yes , Aurora-A , FGFR3 , Flt3 , and Ret ( IC 50 =8 (K i ), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo [1] [2] .

O=C([C@@H](C1CCCCC1)N)NC2=CC3=C(C(C=NNC4=O)=C(N3)C5=CN(N=C5)C)C4=C2

-20°C,2°C to 8°C

12352200