PF-5177624 [1350821-45-2]

MedChem Express

PF-5177624 [1350821-45-2]

5

1350821-45-2

Research Use Only

C25H25FN8O2

488.52

PF-5177624 is a specific and potent inhibitor of PDK1, a key enzyme in the PI3K/AKT signaling pathway that is frequently dysregulated in breast cancer. PDK1 phosphorylates AKT at T308 and other substrates, activating downstream signaling pathways that are important for tumor progression. PF-5177624 blocks IGF-1-stimulated PDK1 activity and downstream AKT and p70S6K phosphorylation, reducing cell proliferation and transformation in breast cancer cells[1].

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