PF-5274857 [1373615-35-0]

MedChem Express

PF-5274857 [1373615-35-0]

10

1373615-35-0

Research Use Only

99.31

C20H25ClN4O3S

436.96

PF-5274857 is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway[1].

O=C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)CCS(=O)(C)=O

-20°C,2°C to 8°C

12131703