PF-915275 (Standard) [857290-04-1]

MedChem Express

PF-915275 (Standard) [857290-04-1]

999

Research Use Only

PF-915275 (Standard) is the analytical standard of PF-915275. This product is intended for research and analytical applications. PF-915275 is a potent, selective and orally active human 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) inhibitor with a Ki of 2.3 nM and an EC50 of 15 nM (in HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively[1][2][3].

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