PF-CBP1 hydrochloride

MedChem Express

PF-CBP1 hydrochloride [2070014-93-4]

10

2070014-93-4

Research Use Only

99.96

C29H37ClN4O3

525.08

PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD). PF-CBP1 inhibits CREBBP and EP300 bromodomains with IC50 of 125 nM and 363 nM respectively. PF-CBP1 hydrochloride reduces LPS-induced inflammatory cytokines expression (IL-1beta, IL-6 and IFN-beta) in primary macrophages. PF-CBP1 hydrochloride also downregulates RGS4 expression cortical neurons and can be used for the research of neurological disorders, including epilepsy and parkinsons disease, et al[1].

CCCOC1=CC=C(CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2CCN5CCOCC5)C=C1.Cl[H]

2°C to 8°C

12352200