PFI-2

MedChem Express

PFI-2 [1627676-59-8]

10

1627676-59-8

Research Use Only

C23H25F4N3O3S

499.52

PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI-2 shows high inhibiting activity with IC 50 value of 2.0??nM and (S)-PFI-2 shows inhibiting activity with IC 50 ?value of?1.0??microM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis [1] [2] .

O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O

12352200