PFK-158

MedChem Express

PFK-158 [1462249-75-7]

10

1462249-75-7

Research Use Only

98.88

C18H11F3N2O

328.29

PFK-158 is a potent and selective PFKFB3 inhibitor with an IC50 value 137 nM. PFK-158 reduces glucose uptake, ATP production, lactate release, and induces apoptosis and autophagy in cancer cells. PFK-158 has broad anti-tumor activity. PFK-158 can also enhance Colistins resistance to bacteria[1][2][3].

O=C(C1=CC=NC=C1)/C=C/C2=NC3=CC(C(F)(F)F)=CC=C3C=C2

-20°C,2°C to 8°C

12352200