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PFKL antibody [C1C3]

GTX105697
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetPFKL
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Overview

  • Supplier
    GeneTex
  • Product Name
    PFKL antibody [C1C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.23 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5211
  • Target name
    PFKL
  • Target description
    phosphofructokinase, liver type
  • Target synonyms
    ATP-PFK, PFK-B, PFK-L, ATP-dependent 6-phosphofructokinase, liver type, 6-phosphofructokinase type B, 6-phosphofructokinase, liver type, liver-type 1-phosphofructokinase, phosphofructo-1-kinase isozyme B, phosphohexokinase
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP17858
  • Protein Name
    ATP-dependent 6-phosphofructokinase, liver type
  • Scientific Description
    Phosphofructokinase (PFK) is a tetrameric enzyme that catalyzes a key step in glycolysis, namely the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate. Separate genes encode a muscle subunit (M) and a liver subunit (L). PFK from muscle is a homotetramer of M subunits, PFK from liver is a homotetramer of L-subunits, while PFK from platelets can be composed of any tetrameric combination of M and L subunits. The protein encoded by this gene represents the L subunit. Alternate splicing results in two transcript variants, one of which is a candidate for nonsense-mediated decay (NMD). [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Wang C, Qiao S, Zhao Y, et al. The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice. Nat Commun. 2023,14(1):959. doi: 10.1038/s41467-023-36712-9
    Read this paper
  • Hu CM, Tien SC, Hsieh PK, et al. High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells. Cell Metab. 2019,29(6):1334-1349.e10. doi: 10.1016/j.cmet.2019.02.005
    Read this paper