Western blot analysis of extracts of various cell lines using PHF19 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using PHF19 Polyclonal Antibody at 1:1000 dilution.
PHF19 Polyclonal Antibody
E-AB-62410
Product group Antibodies
Overview
- SupplierElabscience
- Product NamePHF19 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionPolycomb group (PcG protein that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3 and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at Lys-36 (H3K36me2. Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
- UNSPSC12352203