Phomopsin A [64925-80-0]

AdipoGen Life Sciences

Phomopsin A

10

64925-80-0

Research Use Only

>98%

Warning

C36H45ClN6O12

789.2

Chemical. CAS: 64925-80-0. Formula: C36H45ClN6O12. MW: 789.2. Isolated from Phomopsis leptostromiformis. Macrocyclic heptapeptide mycotoxin. Potent anti-mitotic compound that can cause cell death. Microtubule assembly inhibitor. Binds selectively to dimeric tubulin, inhibiting the formation of the microtubule spindle to block cell division. Binds at a site different from the colchicine binding site and overlapping the vinblastine binding site. Inhibits tubulin-dependent GTP hydrolysis. Binds beta-tubulin from higher organisms but not alpha-tubulin or fungal mycelial tubulin. Causes lupinosis (a degenerative disorder) in livestock fed infected lupins. - Macrocyclic heptapeptide mycotoxin. Potent anti-mitotic compound that can cause cell death. Microtubule assembly inhibitor. Binds selectively to dimeric tubulin, inhibiting the formation of the microtubule spindle to block cell division. Binds at a site different from the colchicine binding site and overlapping the vinblastine binding site. Inhibits tubulin-dependent GTP hydrolysis. Binds beta-tubulin from higher organisms but not alpha-tubulin or fungal mycelial tubulin. Causes lupinosis (a degenerative disorder) in livestock fed infected lupins.

ClC1=CC([C@H](O)[C@@H]2NC)=CC(O[C@@](C)(CC)[C@H](C(N3CC=C[C@H]3C(N/C(C(N/C(C(O)=O)=C/C(O)=O)=O)=C(C)/CC)=O)=O)NC([C@H](C(C)=C)NC2=O)=O)=C1O

-20°C,2°C to 8°C

12352200