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Western Blot analysis of 293T cells with Phospho-Catenin beta (Tyr654) Polyclonal Antibody
Western Blot analysis of 293T cells with Phospho-Catenin beta (Tyr654) Polyclonal Antibody
Western Blot analysis of 293T cells with Phospho-Catenin beta (Tyr654) Polyclonal Antibody

Phospho-Catenin-beta (Y654) Polyclonal Antibody

E-AB-20830
Elabscience
Protein IDP35222
Product group Proteins
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Overview

  • Supplier
    Elabscience
  • Product Name
    Phospho-Catenin-beta (Y654) Polyclonal Antibody
  • Delivery Days Customer
    12
  • Applications Supplier
    WB,IHC,ELISA
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Protein IDP35222
  • Protein Name
    Catenin beta-1
  • Scientific Description
    Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
  • UNSPSC
    12352202