ProductsBack/Phospho-CCND2 (Thr280) Antibody

Western blot analysis of extracts from COLO cells, treated with EGF (200ng/ml, 30mins), using Cyclin D2 (Phospho-Thr280) antibody. The lane on the right is treated with the synthesized peptide.

Phospho-CCND2 (Thr280) Antibody

CSB-PA211813

ApplicationsWestern Blot, ELISA

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetCCND2

Overview

Supplier
Cusabio
Product Name
Phospho-CCND2 (Thr280) Antibody
Delivery Days Customer
20
Applications
Western Blot, ELISA
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID894
Target name
CCND2
Target description
cyclin D2
Target synonyms
KIAK0002, MPPH3, G1/S-specific cyclin-D2
Host
Rabbit
Isotype
IgG
Protein IDP30279
Protein Name
G1/S-specific cyclin-D2
Scientific Description
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C
UNSPSC
41116161

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Phospho-CCND2 (Thr280) Antibody

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