Phospho-MAPKAPK2 (Thr334) Antibody

Cusabio

Phospho-MAPKAPK2 (Thr334) Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

MAPKAPK2

MAPK activated protein kinase 2

MAPKAP-K2, MK-2, MK2, MAP kinase-activated protein kinase 2, MAPKAP kinase 2, mitogen-activated protein kinase-activated protein kinase 2

Rabbit

IgG

MAP kinase-activated protein kinase 2

Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively.

Human, Mouse, Rat

-20°C or -80°C

41116161