Western blot analysis of extracts from HUVEC cells treated with PMA using Pim-1 (Phospho-Tyr309) Antibody.The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from HUVEC cells treated with PMA using Pim-1 (Phospho-Tyr309) Antibody.The lane on the right is treated with the antigen-specific peptide.
Phospho-Pim1 (Tyr309) Antibody
CSB-PA174999
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
Overview
- SupplierCusabio
- Product NamePhospho-Pim1 (Tyr309) Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- HostRabbit
- IsotypeIgG
- Protein IDP06803
- Protein NameSerine/threonine-protein kinase pim-1
- Scientific DescriptionProto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Selten G., Cell 46:603-611(1986). Saris C.J., EMBO J. 10:655-664(1991). Maita H., Eur. J. Biochem. 267:5168-5178(2000).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203