WB analysis of bovine cardiac preparation untreated or treated with PKA using GTX15000 Phospholamban (phospho Ser16) antibody. Dilution : 2microg/ml
WB analysis of bovine cardiac preparation untreated or treated with PKA using GTX15000 Phospholamban (phospho Ser16) antibody. Dilution : 2microg/ml
Phospholamban (phospho Ser16) antibody
GTX15000
ApplicationsWestern Blot
Product group Antibodies
ReactivityBovine, Human, Rabbit
TargetPLN
Overview
- SupplierGeneTex
- Product NamePhospholamban (phospho Ser16) antibody - Orthogonal Validated
- Delivery Days Customer9
- Application Supplier NoteWB: 0.5-2microg/ml (bovine cardiac preparation incubated with 10microg PKA for 10 minutes). *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID5350
- Target namePLN
- Target descriptionphospholamban
- Target synonymscardiac phospholamban; CMD1P; CMH18; PLB
- HostRabbit
- IsotypeIgG
- Protein IDP26678
- Protein NameCardiac phospholamban
- Scientific DescriptionThe protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
- ReactivityBovine, Human, Rabbit
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Calcium dysregulation increases right ventricular outflow tract arrhythmogenesis in rabbit model of chronic kidney disease. Huang SY et al., 2021 Dec, J Cell Mol MedRead more
- Sacubitril/Valsartan Therapy Ameliorates Ventricular Tachyarrhythmia Inducibility in a Rabbit Myocardial Infarction Model. Chang PC et al., 2020 Jun, J Card FailRead more
- Protein kinase A activity at the endoplasmic reticulum surface is responsible for augmentation of human ether-a-go-go-related gene product (HERG). Sroubek J et al., 2011 Jun 17, J Biol ChemRead more