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WB analysis of bovine cardiac preparation untreated or treated with PKA using GTX15000 Phospholamban (phospho Ser16) antibody. Dilution : 2microg/ml

Phospholamban (phospho Ser16) antibody

GTX15000

ApplicationsWestern Blot

Product group Antibodies

TargetPLN

Overview

Supplier
GeneTex
Product Name
Phospholamban (phospho Ser16) antibody
Delivery Days Customer
9
Application Supplier Note
WB: 0.5-2microg/ml (bovine cardiac preparation incubated with 10microg PKA for 10 minutes). *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID5350
Target name
PLN
Target description
phospholamban
Target synonyms
CMD1P, CMH18, PLB, phospholamban, cardiac phospholamban
Host
Rabbit
Isotype
IgG
Protein IDP26678
Protein Name
Phospholamban
Scientific Description
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Huang SY, Chen YC, Kao YH, et al. Calcium dysregulation increases right ventricular outflow tract arrhythmogenesis in rabbit model of chronic kidney disease. J Cell Mol Med. 2021,25(24):11264-11277. doi: 10.1111/jcmm.17052
Read this paper
Chang PC, Wo HT, Lee HL, et al. Sacubitril/Valsartan Therapy Ameliorates Ventricular Tachyarrhythmia Inducibility in a Rabbit Myocardial Infarction Model. J Card Fail. 2020,26(6):527-537. doi: 10.1016/j.cardfail.2020.03.007
Read this paper
Sroubek J, McDonald TV. Protein kinase A activity at the endoplasmic reticulum surface is responsible for augmentation of human ether-a-go-go-related gene product (HERG). J Biol Chem. 2011,286(24):21927-36. doi: 10.1074/jbc.M110.201699
Read this paper