Phototrexate [2268033-83-4]

TargetMol Chemicals

Phototrexate [2268033-83-4]

10

Research Use Only

Phototrexate

C20H19N7O5

437.41

Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate. Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark.cis-Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared withtrans-Phototrexate (IC50 = 34 microM).

3 years

NC=1C2=C(C=CC(/N=N/C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=C2)N=C(N)N1

-20°C

12352200