Bio-Connect

Phthalazinone pyrazole [880487-62-7]

HY-12564
MedChem Express
CAS Number880487-62-7
Product group Chemicals
Estimated Purity98.0
Molecular Weight317.34
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Phthalazinone pyrazole [880487-62-7]
  • Delivery Days Customer
    10
  • CAS Number
    880487-62-7
  • Certification
    Research Use Only
  • Estimated Purity
    98.0
  • Molecular Formula
    C18H15N5O
  • Molecular Weight
    317.34
  • Scientific Description
    Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC50 of 0.031 microM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells[1][2].
  • SMILES
    O=C1C2=CC=CC=C2C(NC3=NNC(C)=C3)=NN1C4=CC=CC=C4
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200