Physcion [521-61-9]

MedChem Express

Physcion [521-61-9]

10

521-61-9

Research Use Only

99.00

C16H12O5

284.26

Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC50 and Kd values of 38.5 microM and 26.0 microM, respectively. Additionally, Physcion is an inhibitor of the bTLR4/NF-kappaB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells[1][2][3][4][5].

O=C1C2=C(C=C(C)C=C2O)C(C3=CC(OC)=CC(O)=C13)=O

-20°C,2°C to 8°C

12352200