PI-103

MedChem Express

PI-103 [371935-74-9]

10

371935-74-9

99.82

C19H16N4O3

348.36

PI-103 is a potent PI3K and mTOR inhibitor with IC 50 s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110alpha , p110beta , p110delta , p110gamma , mTORC1 , and mTORC2 . PI-103 also inhibits DNA-PK with an IC50 of 2 nM. PI-103 induces autophagy [1] [2] [3] [4] .

OC1=CC(C2=NC3=C(C(N4CCOCC4)=N2)OC5=C3C=CC=N5)=CC=C1

-20°C,2°C to 8°C

12352200