PI3K-IN-47

MedChem Express

PI3K-IN-47

14

Research Use Only

C50H46F4N8O8S2

1027.07

PI3K-IN-47 (Compound 27) is a bivalent PI3K inhibitor (IC50: 0.44 nM for PI3Kalpha, 7.18 nM, 13.92 nM, 22.83 nM for PI3Kbeta, PI3Kgamma, PI3Kdelta). PI3K-IN-47 induces cell cycle arrest in G1 phase, inhibits colony formation and cell migration. PI3K-IN-47 inhibits tumor growth in HGC-27 xenograft mice[1].

CC1=C2C=C(C3=CN=C(OC)C(NS(C4=CC=C(F)C=C4F)(=O)=O)=C3)C=C(OCCCCCCCCOC5=CC(C6=CN=C(OC)C(NS(C7=CC=C(F)C=C7F)(=O)=O)=C6)=CC8=C(C)N=CN=C58)C2=NC=N1

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