PI3K/AKT-IN-4

MedChem Express

PI3K/AKT-IN-4

9

Research Use Only

C19H26O2

286.41

PI3K/AKT-IN-4 (compound 3) is a diterpenoid that can be isolated from the roots and rhizomes of Salvia castanea Dielsf. PI3K/AKT-IN-4 has antitumor activity, inhibiting cell viability and proliferation (IC50=4.72 microM) and promoting apoptosis by blocking the G0/G1 phase of the Hep3B cell cycle, inducing mitochondrial dysfunction and oxidative stress. In addition, PI3K/AKT-IN-4 inhibits hepatocellular carcinoma by inhibiting the PI3K-Akt signaling pathway and binding to PARP1 and CDK2 targets[1].

OC1=CC2=C(C=C(C)C1=O)CC[C@@]3([H])C(C)(C)CCC[C@@]32C

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