PI3Kalpha-IN-12

MedChem Express

PI3Kalpha-IN-12 [2966861-50-5]

14

Research Use Only

C28H36F2N10O5S3

726.84

PI3Kalpha-IN-12 (compound 13) is a highly selective PI3Kalpha inhibitor (IC50: 1.2 nM). PI3Kalpha-IN-12 inhibits HCT-116 and U87-MG with IC50s values of 0.83 and 1.25 microM, respectively. PI3Kalpha-IN-12 (40 mg/kg; IP) causes tumor regression in a U87-MG cell line xenograft mouse model[1].

S=C(N1CCN(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)CC1)SCC(N6CCN(S(=O)(C)=O)CC6)=O

12131703