PI3Kalpha-IN-21
HY-158029
Molecular Weight558.67
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NamePI3Kalpha-IN-21
- Delivery Days Customer5
- CertificationResearch Use Only
- Molecular FormulaC38H30N4O
- Molecular Weight558.67
- Scientific DescriptionPI3Kalpha-IN-21 (compound 8) is a PI3Kalpha inhibitor, and its selectivity for PI3Kalpha is 10.41/16.99/37.53 times higher than PI3Kbeta/gamma/delta respectively (IC50: 96.89/568.24/397.48 nM ). PI3Kalpha-IN-21 inhibits cancer cell activity, proliferation, and migration, and induces mitochondrial apoptosis through the PI3K/Akt/mTOR pathway. PI3Kalpha-IN-21 exhibits in vivo antitumor potency in a mouse model of non-small cell lung cancer[1].
- SMILESCC1=NC2=C(C(N(C3=CC=C4C(/C(C(N4CC5=CC=CC=C5)=O)=C/C6=CC=CC=C6)=C3)CC7=CC=CC=C7)=N1)C=CC=C2
- UNSPSC12352200