PI3Kalpha-IN-22

MedChem Express

PI3Kalpha-IN-22

5

Research Use Only

C24H23F2N5O3

467.47

PI3Kalpha-IN-22 (Compound 17) is an orally active, potent and selective inhibitor of PI3KalphaH1047R, with an IC50 of 1 nM for pAKT T47D AlphaLISA. PI3Kalpha-IN-22 can induce tumor regressions in the HCC1954 tumor model in mice[1].

CC(C=C([C@H](NC1=CC=CC=C1C(O)=O)C)C2=NC(N3CCC(F)(F)CC3)=C4C#N)=CN2C4=O

12352200