PI3Kalpha-IN-8

MedChem Express

PI3Kalpha-IN-8 [2315320-24-0]

10

Research Use Only

C26H27BrN4O2

507.42

PI3Kalpha-IN-8 (Compound 9g) is a selective PI3Kalpha inhibitor with an IC50 of 0.012 microM. PI3Kalpha-IN-8 increases intracellular reactive oxygen species level, decreases mitochondrial membrane potential and induces apoptosis[1].

C[C@@]12C3=CC(Br)=C(N=C(N4)NC5=CC=C(C=C5)C#N)C4=C3CC[C@@]1([H])[C@@](C)(CCC2)C(OC)=O

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