PI3Kdelta-IN-21
HY-158688
Molecular Weight405.84
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NamePI3Kdelta-IN-21
- Delivery Days Customer5
- CertificationResearch Use Only
- Molecular FormulaC19H16ClN9
- Molecular Weight405.84
- Scientific DescriptionPI3Kdelta-IN-21 (Compound 31) is a selective inhibitor for phosphoinositide 3-kinases delta (PI3Kdelta), with an IC50 of 13.6 nM. PI3Kdelta-IN-21 inhibits proliferation and differentation of T cells through PI3K/AKT/mTOR signaling pathway. PI3Kdelta-IN-21 exhibits good pharmacokinetic characters in rat model, and attenuates the experimental autoimmune encephalomyelitis in myelin oligodendrocyte glycoprotein (MOG)-induced EAE model[1].
- SMILESC[C@@H](C1=CN(C2=CC(Cl)=CN=C21)C3=CC=CN=C3)NC4=NC(N)=NC(N)=C4C#N
- UNSPSC12352200