PI3Kdelta-IN-22

MedChem Express

PI3Kdelta-IN-22

5

Research Use Only

C27H35FN8O4S

586.68

PI3Kdelta-IN-22 (Compound 26) is a selective inhibitor for PI3Kdelta with pKi of 9.3. PI3Kdelta-IN-22 inhibits PI3Kdelta-AKT signaling pathway in THP-1 cells, with pIC50 of 9.4. PI3Kdelta-IN-22 exhibits good pharmacokinetic characters in rats[1].

O=C1N(C(C)(C)C)N=CC([C@@H](N2N=C(C3=CC(F)=CC(O)=C3)C4=C2N=CN=C4N)C)=C1SCCN(CCO)CCO

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