PI3Kdelta-IN-25

MedChem Express

PI3Kdelta-IN-25

999

Research Use Only

C26H28N6O4S2

552.67

PI3Kdelta-IN-25 is an orally active selective PI3Kdelta inhibitor (IC50 = 2.1 nM). PI3Kdelta-IN-25 has IC50s of 272, 285, and 1171 nM for PI3Kalpha, PI3Kgamma, and PI3Kbeta, respectively. PI3Kdelta-IN-25 inhibits AKT Ser473 phosphorylation, suppresses Treg cell proliferation, and downregulates PD-L1 expression in B16F10 cells. PI3Kdelta-IN-25 exhibits anticancer effects in B16F10 melanoma and Lewis lung cancer mouse models by reducing tumor-infiltrating Treg cells and enhancing immune responses. PI3Kdelta-IN-25 is potentially useful in the study of melanoma, lung cancer, and other cancers[1].

O=C(N1CC[C@H](NC2=NC=NC3=C2C=C(C4=CC(NS(C5=CC=C(C=C5)C)(=O)=O)=C(N=C4)OC)S3)C1)CC

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