PI3Kdelta/HDAC6-IN-1

MedChem Express

PI3Kdelta/HDAC6-IN-1

999

Research Use Only

C34H38N10O4

650.73

PI3Kdelta/HDAC6-IN-1 (Compound 22E) is an orally active and dual inhibitor of PI3Kdelta and HDAC6 with IC50 values of 2.4 nM and 6.2 nM, respectively. PI3Kdelta/HDAC6-IN-1 exhibits potent antiproliferative effects on non-Hodgkin lymphoma (NHL) cells and possesses in vivo antitumor activity without significant toxicity. PI3Kdelta/HDAC6-IN-1 arrests the cell cycle at the G0/G1 phase and induces apoptosis. PI3Kdelta/HDAC6-IN-1 blocks the PI3K/AKT/mTOR signaling pathway and increases the acetylation levels of alpha-tubulin and histone H3[1].

CCC(N1C2=NC(N(C)C(CN3C(CN(CC4=CC=C(/C=C/C(NO)=O)C=C4)CC3)=O)=N5)=C5C(N6CCOCC6)=N2)=NC7=C1C=CC=C7

12352200