PI3K/HDAC-IN-4

MedChem Express

PI3K/HDAC-IN-4

5

Research Use Only

C28H35F3N12O3

644.65

PI3K/HDAC-IN-4 (Compound 31f) is a PI3K/HDAC dual inhibitor (IC50: 0.2microM). PI3K/HDAC-IN-4 shows high selectivity for HDAC1-3 (IC50 values of 75.5 nM, 70.9 nM, and 1.9 nM, respectively). PI3K/HDAC-IN-4 is a potent PIK3 inhibitor with IC50 values of 2.5 nM, 80.5 nM, 10.0 nM, and 57.2 nM for PI3Kalpha, beta, delta, and gamma, respectively. PI3K/HDAC-IN-4 significantly induces tumor cell apoptosis by simultaneously inhibiting the PI3K/AKT/mTOR signaling pathway and HDAC1-3. PI3K/HDAC-IN-4 exhibits potent antiproliferative activity in a variety of tumor cell lines (e.g., MV4-11, Jeko-1, HL60, and MCF-7, with IC50 values of 0.2, 0.9, 0.8, and 1.5 microM, respectively). PI3K/HDAC-IN-4 can be used in the study of lymphoma and leukemia[1].

CCCNNC(C1=CC=C(C=C1)CNC(N2CCN(CC2)C3=NC(C4=CN=C(N)N=C4C(F)(F)F)=NC(N5CCOCC5)=N3)=O)=O

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