PIAS1 (C) Antibody, Rabbit Polyclonal

Biorbyt

PIAS1 antibody

16

WB:1:1000-1:5000,IP:1:50-1:100,IF:1:100-1:200,IHC:1:100-1:200 IF, IHC, IP, WB

Pias1

protein inhibitor of activated STAT 1

2900068C24Rik; Ddxbp; Ddxbp1; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein ligase PIAS1; GB; GBP; protein inhibitor of activated STAT protein 1; RING-type E3 ubiquitin transferase PIAS1

E3 SUMO-protein ligase PIAS1

Rabbit polyclonal to PIAS1.E3 SUMO-protein ligase PIAS1 is a member of the mammalian PIAS (protein inhibitor of activatedSTAT-1 (signal transducer and activator of transcription-1)) family, which contains a putative zincbindingmotif and a highly acidic region. PIAS1 functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMOtetheringfactor. PIAS1 plays a crucial role as a transcriptional coregulation in various cellularpathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.In vitro, PIAS1 binds A/T-rich DNA. The effects of the transcriptional coregulation, transactivation orsilencing, may vary depending upon the biological context.

-20°C

12352203