Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using PIAS4 antibody.
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using PIAS4 antibody.
PIAS4 Antibody
CSB-PA577177
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetPIAS4
Overview
- SupplierCusabio
- Product NamePIAS4 Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID51588
- Target namePIAS4
- Target descriptionprotein inhibitor of activated STAT 4
- Target synonymsE3 SUMO-protein ligase PIAS4; Piasg; PIAS-gamma; PIASY; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein gamma; protein inhibitor of activated STAT protein PIASy; RING-type E3 ubiquitin transferase PIAS4; zinc finger, MIZ-type containing 6; ZMIZ6
- HostRabbit
- IsotypeIgG
- Protein IDQ8N2W9
- Protein NameE3 SUMO-protein ligase PIAS4
- Scientific DescriptionFunctions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Zendra E. Zehner, AACR Meeting Abstracts, Apr 2005; 2005: 456. Amador Albor, J. Biol. Chem., Sep 2006; 281: 25850 - 25866. Christina-Maria Hecker, J. Biol. Chem., Jun 2006; 281: 16117 - 16127. Yun Zhao, Stem Cells, Apr 2007; 10.1634.
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C
- UNSPSC12352203