Piccolo Antibody (OASE00136)

Aviva Systems Biology

Piccolo Antibody (OASE00136)

23

ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry

Research Use Only

Monoclonal

6H9-B6

1 mg/ml

Unconjugated

Pclo

piccolo (presynaptic cytomatrix protein)

Acz, Pico, protein piccolo, aczonin, brain-derived HLMN protein, multidomain presynaptic cytomatrix protein

Mouse

IgG2b

Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2).

-20°C

12352203