Picrotoxinin [17617-45-7]

MedChem Express

Picrotoxinin [17617-45-7]

10

17617-45-7

Research Use Only

99.82

C15H16O6

292.28

Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. Picrotoxinin inhibits alpha1beta2gamma2L GABAA receptor with an IC50 of 1.15 microM[1].

O=C1[C@]([C@@H]2C(C)=C)([H])[C@]3(O)C[C@]4([H])[C@](O4)(C(O5)=O)[C@]3(C)[C@@]5([H])[C@]2([H])O1

-20°C,2°C to 8°C

12352200