PIEZO1 Antibody

Cusabio

PIEZO1 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

PIEZO1

piezo type mechanosensitive ion channel component 1 (Er blood group)

DHS, ER, FAM38A, LMPH3, LMPHM6, Mib, piezo-type mechanosensitive ion channel component 1, family with sequence similarity 38, member A, membrane protein induced by beta-amyloid treatment

Rabbit

IgG

Piezo-type mechanosensitive ion channel component 1

Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).

Human

-20°C or -80°C

41116161