PIK-75 [372196-67-3]

MedChem Express

PIK-75 [372196-67-3]

5

372196-67-3

Research Use Only

98.72

C16H14BrN5O4S

452.28

PIK-75 is a reversible DNA-PK and p110alpha-selective inhibitor, which inhibits DNA-PK, p110alpha and p110gamma with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110alpha >200-fold more potently than p110beta (IC50=1.3 microM)[1][2]. PIK-75 induces apoptosis[3].

O=S(C1=CC([N+]([O-])=O)=CC=C1C)(N(C)/N=C/C2=CN=C3C=CC(Br)=CN32)=O

2°C to 8°C

12352200