PIK-C98 [691388-62-2]
HY-12491
CAS Number691388-62-2
Product group Chemicals
Molecular Weight349.23
Overview
- SupplierMedChem Express
- Product NamePIK-C98 [691388-62-2]
- Delivery Days Customer9
- CAS Number691388-62-2
- CertificationResearch Use Only
- Molecular FormulaC16H10Cl2N2OS
- Molecular Weight349.23
- Scientific DescriptionPIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 microM for alpha, beta, delta, and gamma isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma[1].
- SMILESN#C/C(C(N)=S)=C\C=C\C1=CC=C(C2=C(Cl)C=CC(Cl)=C2)O1
- UNSPSC12352200