Pim-1/2 kinase inhibitor 2 [2918764-16-4]

TargetMol Chemicals

Pim-1/2 kinase inhibitor 2 [2918764-16-4]

16

Research Use Only

C25H19ClN4O3

458.9

Compound 5b, designated as Pim-1/2 kinase inhibitor 2, acts as a competitive inhibitor of both PIM-1 and PIM-2 kinases, demonstrating IC50 values of 1.31 microM and 0.67 microM, respectively. This compound exhibits potent in-vitro anticancer activity against various cancer cell lines, including myeloid leukemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2), while showing low cytotoxicity to the normal human lung fibroblast Wi-38 cell line [1].

C(#N)C1=C(C=2C(=NC3=C(C2)C=C(Cl)C=C3)N4CCOCC4)C=C(NC1=O)C5=CC(O)=CC=C5

-20°C

51202000